Fc Receptors, Antibodies and MicroEnvironment




The FRAME team studies the interactions between proteins expressing an IgG Fc portion (therapeutic antibodies and pathogenic antibodies, fusion proteins) and the Fcγ and FcRn receptors, and the resulting cellular responses. The team seeks to understand how certain elements of the microenvironment (proteases, endogenous IgG ...) have an impact on these interactions, knowing that this microenvironment itself can vary according to the diseases concerned: cancer, inflammation, etc. for therapeutic antibodies and fusion proteins; thrombocytopenia induced by heparin in our pathogenic antibody model. The FRAME team is particularly interested in the FcγRIIIA / FcγRIIA receptors and the FcRn receptors and the cellular responses they trigger: antibody-dependent cellular cytotoxicity (FcγRIIIA), platelet aggregation or secretion (FcγRIIA), antibody recycling / distribution (FcRn ), anti-tumor response (FcRn).