Sélection des publications de l'équipe 4


• Baltus, C. ; Jorda, R.; Marot, C. ; Berka, K. ; Bazgier, V. ; Krystof, V. ; Prié, G. ; Viaud-Massuard, M.C.
Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/cyclin E inhibitors
Eur. J. of Med. Chem. 2016, 108, 701-719.

• Brachet, G.; Respaud, R.; Arnoult, C.; Henriquet, C.; Dhommee, C.; Viaud-Massuard, M.-C.; Heuze-Vourc’h, N.; Joubert, N.; Pugniere, M.; Gouilleux-Gruart, V.
Increment in drug loading on an antibody-drug conjugate increases its binding to the human Neonatal Fc Receptor in vitro.
Mol. Pharm. 2016 in press. DOI: 10.1021/acs.molpharmaceut.6b00082

Croix, C.; Prié, G.; Chaulet, C.; Viaud-Massuard, M.-C.

Rhodium-catalyzed 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one derivatives

J. Org. Chem. 2015, 80, 3264-3269.

• Joubert, N.; Viaud-Massuard, M.-C.
Antibody-Drug Conjugates: Historical Developments and Mechanisms of Action.
Chapter in eBook "Optimizing Antibody-Drug Conjugates for Targeted Delivery of Therapeutics",
Future Medicine, 2015, 6-21.
Plas A, Martin C, Joubert N, Viaud-Massuard MC.
Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole
Org. Lett. 2015 in press
DOI: 10.1021/acs.orglett.5b02173

• Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale J-C, Jacquiet P, Brossier F, Gueiffier A, Dimier-Poisson I, Enguehard-Gueiffier C.
A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity.
European Journal of Medicinal Chemistry, 2015, 89, 386-400.

Joubert N, Viaud-Massuard MC, Respaud R.
New Antibody-Drug Conjugates and their use in therapy.
Brevet Fr. Demande 2015FR1356837.

Joubert N, Viaud-Massuard MC, Respaud R.
Novel Antibody-Drug Conjugates and the use of same in therapy. PCT WO2015004400.
Cette demande est accompagnée de deux demandes divisionnaires.


• Obando Montoya E J, Mélin C, Blanc N, Lanoue A, Foureau E, Boudesocque L, Prie G, Simkin AJ, Crèche J, Atehortùa L, Giglioli-Guivarc’h N, Clastre M, Courdavault V, Papon N.
Disrupting the methionine biosynthetic pathway in Candida guilliermondii: characterization of the MET2 gene as counter-selectable marker.
Yeast 2014, 31, 243-251.

• Bouchet N, Jaillet J, Gabant G, Brillet B, Briseño-Roa L, Cadene M, Augé-Gouillou C.
cAMP protein kinase phosphorylates the Mos1 transposase and regulates its activity: evidences from mass spectrometry and biochemical analyses.
Nucleic Acids Res. 2014, 42 : 1117-1128

Pflieger A, Jaillet J, Petit A, Augé-Gouillou C, Renault S.
Target capture during Mos1 transposition.
J Biol Chem. 2014,289 : 100-111

Respaud R, Marchand D, Parent C, Pelat T, Thullier P, Tournamille JF, Viaud-Massuard MC, Diot P, Si-Tahar M, Vecellio L, Heuzé-Vourc'h N.
Effect of formulation on the stability and aerosol performance of a nebulized antibody.
MAbs. 2014 Aug 5;6(5).